Chloe, a diamond-clad, bootie wearing Beverly Hills Chihuahua enjoys her luxurious lifestyle so much, she hardly notices Papi, a hilarious Chihuahua who happens to be crazy for Chloe. But when the most pampered pooch gets lost in Mexico with only a street-wise German Shepherd to help her find her way home, Papi heads south of the border--joining forces with a motley crew: three dogs, two humans, a sly rat and a nervous iguana--to rescue his true love.